This research addresses the Prize-Collecting Traveling Salesman Problem (PCTSP) under demand uncertainty, a challenge in route optimization where unmet demands incur penalties. Traditional deterministic models fail to capture real-world vari- ability. In this context, a new methodology is proposed that integratess Artificial Intelligence (AI) and simheuristic techniques, which arise from the combination of simulations with heuristics, to improve decision making in uncertain environments. Specifically, Machine Learning models are used to predict demand by obtain- ing an approximation to the most affine deterministic world assumption, while clustering methods generate realistic demand scenarios. All this giving a more realistic approach replacing the classical ones with Monte Carlo simulations. A simheuristic approach combining GRASP with simulations will be used, aided by Machine Learning methods to improve the evaluation of solutions under stochastic conditions.