This special issue of Networks is dedicated to the seventh conference of the EURO Working Group on Vehicle Routing and Logistics Optimization (VeRoLog 2019) held in Seville, Spain, on June 2 to 6, 2019. The event brought together the large community of researchers and practitioners interested in vehicle routing optimization and its relationship with logistics. Specifically, the meeting saw the participation of more than 200 people from five continents. As in previous VeRoLog conferences, the scientific program was rich and included two plenary talks about designing routes for vehicles and drivers and the importance of routing at Amazon.com, two tutorials related to the efficient implementation in this field and variants, formulations and exact methods for multi-trip vehicle routing problems, and two brainstorming sessions organized by companies active in vehicle routing optimization. Furthermore, 173 high-quality methodological contributions, relevant real-world applications, and case studies from industry and the service sector were presented in 35 parallel sessions. The special issue collects an important selection of these contributions covering various aspects of the research on vehicle routing and its applications.